Description
Selling Isotonitazepyne (N-pyrrolidino isotonitazene
Isotonitazepyne (N-pyrrolidino isotonitazene) is a benzimidazole derivative with potent opioid effects, which has been sold as a designer drug over the internet. It was first detected in Russia in 2022,[1] and has since been found around the world, tentatively identified in Australia[2] and New Zealand,[3] though it can be difficult to distinguish from the isomeric compound protonitazepyne. It is specifically listed as an illegal drug in the US state of Virginia.
Description
Isotonitazepyne (N-pyrrolidino isotonitazene) is an opioid drug derivative of benzimidazole, a strong analgesic, a derivative of the compound isotonitazene. This drug was first discovered in 2022 as a designer drug for research purposes.
Chemistry
Isotonitazepyne is an analogue of isotonitazene and has a related structure, similar in structure to compound protonitazepyne.
Pharmacology, Pharmacodynamic
Studies have shown that Isotonitazepyne acts as a powerful opioid receptor agonist and acts as a strong analgesic, causing sedative and hypnotic effects, causing the euphoria inherent in benzimidazole opioids.
Toxicological and pharmacological properties in the process of studying on rodents in laboratory conditions.
Side effects
In chemical studies and tests, it is necessary to approach the dosages of this substance as carefully as possible, since high dosages of this substance, since high dosages of this substance can cause respiratory depression, vomiting, itching, delirium.
Application in medicine
Isotonitazepyne is a designer research drug and has never been used for medical purposes.
Legal status
US(state of Virginia): This is an analogue of an isotonitazine, illegal.
Technical Information:
Product Name Isotonitazepyne
Synonyms N-Pyrrolidino Isotonitazene, Isotonitazepyne HCL
IUPAC Name 5-nitro-2-[4-(2-propoxy)benzyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-benzo[d]imidazole
CAS Number
Molecular Formula C23H28N4O3
Formula Weight 408.5 g/mol
InChi Code InChI=1S/C23H28N4O3/c1-17(2)30-20-8-5-18(6-9-20)15-23-24-21-16-19(27(28)29)7-10-22(21)26(23)14-13-25-11-3-4-12-25/h5-10,16-17H,3-4,11-15H2,1-2H3
InChi Key VRKDSDBBRNHHCR-UHFFFAOYSA-N
SMILES CC(C)OC1=CC=C(C=C1)CC2=NC3=C(N2CCN4CCCC4)C=CC(=C3)[N+](=O)[O-]
Solubility
DMF: 10 mg/ml
DMSO: 10 mg/ml
PBS (pH 7.2): 1 mg/ml
Formulation A crystalline solid
Purity ≥98%
Disclaimer of liability
Isotonitazepyne is intended only as a substance for scientific and research purposes in special laboratory conditions in compliance with all standards and safety measures.
You can buy Isotonitazepyne online at ChemicalNS company right now and participate in our bonus program, or you can become our partners.
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-We are a chemical company that has proven itself in the chemical industry market, which is ready to share its experience in scientific circles and ready to supply innovative chemical products in the scientific environment, for research and tests.
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-Product purity 98-99%.
-You will receive a ZIP Pack, a sealed aluminum foil package containing the research product
N-Pyrrolidino Isotonitazene (Isotonitazepyne) is an opioid drug, isotonitazene metabolite, has the property of actively affecting the m-opioid receptors, which causes strong analgesic and soothing effects..
This drug is many times higher than the effect of morphine, depending on the method of administration of the drug. High dosages of this substance can cause a number of side effects, such as vomiting, confusion, respiratory depression, up to a fatal outcome, studies have been conducted on rodents.
N-Pyrrolidino Isotonitazene is highly likely to cause opioid dependence.
N-Pyrrolidino Isotonitazene is a research substance and its legal status is not fully clear, it is intended only for research and tests in specially equipped laboratories.
This drug has never been used in medicine and is only sold as a designer drug for opioid potency testing in private labs.
You can buy N-Pyrrolidino Isotonitazene online at teamchemists.com
Product information
IUPAC 2-(4-isoprop
5-nitro-2-[4-(2-propoxy)benzyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-benzo[d]imidazole
Synonyms N-Pyrrolidino Isotonitazene
CAS
Formula C23H28N4O3 • C6H8O7
Molecular Weight 600.6
Purity 98.0 % min.
Formulations A crystalline solid, Powder
Solubility
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- PBS (pH 7.2): 1 mg/ml
InChi Code
InChI=1S/C23H28N4O3.C6H8O7/c1-17(2)30-20-8-5-18(6-9-20)15-23-24-21-16-19(27(28)29)7-10-22(21)26(23)14-13-25-11-3-4-12-25;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-10,16-17H,3-4,11-15H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChi Key
XZGLLCLVIOGQGU-UHFFFAOYSA-N
Shipping & Storage Information
Isotonitazepyne, chemically known as N-pyrrolidino isotonitazene, is a synthetic opioid belonging to the benzimidazole family of opiates. It acts primarily as an agonist at the µ-opioid receptor, with effects and potency comparable to other opioids like fentanyl and its analogs. The compound has a molecular structure that facilitates strong binding affinity to opioid receptors, resulting in significant analgesic and euphoric effects.
Mechanism of Action
Isotonitazepyne exerts its effects by binding to the µ-opioid receptors located in the central nervous system (CNS). By mimicking the action of endogenous opioid peptides, it predominantly produces analgesia, euphoria, and a sense of relaxation. The activation of these receptors leads to the inhibition of ascending pain pathways, alteration in the perception of pain, and increased pain tolerance.
Dosage and Administration
The dosages of Isotonitazepyne vary significantly between individuals, and it should be approached with extreme caution due to its high potency. For therapeutic purposes, microgram to low milligram ranges are suggested, starting from as low as 50 micrograms. Due to the lack of extensive clinical trials and officially sanctioned guidelines, all dosing information should be considered anecdotal and approached with caution.
Effects
The primary effects of Isotonitazepyne include intense analgesia, sedation, and euphoria, which are common among potent opioids. Secondary effects can include respiratory depression, decreased gastrointestinal motility, and alterations in mental status. The onset of effects typically occurs within minutes when administered intravenously, with a duration of action that can last several hours depending on the dose.
Side Effects
Common side effects associated with Isotonitazepyne use include, but are not limited to, nausea, vomiting, constipation, and profound sedation. Serious side effects involve respiratory depression, which can be fatal without prompt medical intervention, particularly at high doses or when combined with other depressants.
Harm Reduction
Harm reduction strategies are critical when handling substances like Isotonitazepyne. These include:
- Starting with the lowest possible dose to assess tolerance.
- Avoiding polydrug use, especially with other CNS depressants like benzodiazepines or alcohol.
- Having naloxone accessible as an antidote for opioid overdose.
- Using in a safe environment and ideally with a sober companion who can assist in case of an emergency.
In conclusion, while Isotonitazepyne may offer significant analgesic potency, it carries a high risk of dependence and fatal overdose. Extreme caution should be exercised, and it should only be used under strict conditions that prioritize safety and monitoring.
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- Selling Isotonitazepyne (N-pyrrolidino isotonitazene
- Selling Isotonitazepyne (N-pyrrolidino isotonitazene
- Selling Isotonitazepyne (N-pyrrolidino isotonitazene
- Selling Isotonitazepyne (N-pyrrolidino isotonitazene
- Selling Isotonitazepyne (N-pyrrolidino isotonitazene
- Selling Isotonitazepyne (N-pyrrolidino isotonitazene
- Selling Isotonitazepyne (N-pyrrolidino isotonitazene
- Selling Isotonitazepyne (N-pyrrolidino isotonitazene
- Selling Isotonitazepyne (N-pyrrolidino isotonitazene
- Selling Isotonitazepyne (N-pyrrolidino isotonitazene
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