Buy isotonitazene powder online. Isotonitazene is a benzimidazole-derived opioid analgesic drug related to etonitazene, which has been sold as a designer drug. It has only around half the potency of etonitazene in animal studies, but it is likely even less potent in humans as was seen with etonitazene (1000 times as potent as morphine in animal models yet only 60 times as potent in humans).^[2] Isotonitazene (obtained from an online vendor) was fully characterized in November 2019 in a paper where the authors performed a full analytical structure elucidation in addition to determination of the potency at the μ-opioid receptor using a biological functional assay in vitro. While isotonitazene was not compared directly to morphine in this assay, it was found to be around 2.5 times more potent than hydromorphone and slightly more potent than fentanyl.

Side effects

Side effects of benzimidazole derived opioids are likely to be similar to those of fentanyl, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening.^[15]

Isotonitazene has been detected in multiple fatalities in Europe since March 2019^[16] and in the U.S. since August 2019, as reported by NPS Discovery, the Center for Forensic Science Research and Education, and NMS Labs.^[17][18]

Legal status

Where to Purchase Isotonitazene Powder Online
Isotonitazene (Item No. 27255) is an analytical reference material categorized as an opioid. Isotonitazene is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. Selling isotonitazene powder online

Isotonitazene Powder Description
Isotonitazene is marketed as a safe alternative to regulated opioids online, however, the market’s extent is unknown.
In a few countries, it also appears to have been available on the black market for opioids. The most serious acute health danger from using isotonitazene is likely to be respiratory depression, which in overdose could result in apnoea, respiratory arrest, and death. This is similar to other opioid analgesics.
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“We will always be reacting when it comes to changes in the drug supply. It’s why we have to make sure we have the resources needed to keep people alive and connect them to services – so that we can reduce deaths and reduce harm,” he added. Selling isotonitazene powder online

The US Drug Enforcement Administration issued a notice of intent to publish a temporary order to schedule isotonitazene in Schedule I of the Controlled Substances Act,^[19] which came into effect on 20 August 2020

What is isotonitazene? A drug more powerful than fentanyl is circulating in Montreal

Isotonitazene, a synthetic opioid, is circulating in Montreal and its effects are devastating.

Most recently, a 15-year-old boy died on Dec. 21 after ingesting the drug, which is considered more potent than fentanyl.

Mathis Boivin apparently thought he was taking oxycontin.

Isotonitazene is an opiate “like any other. [It is] very powerful,” Dr. Alain Vadeboncoeur, an emergency physician, told Noovo Info.

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“It appeared in 2020, but we didn’t talk about it much,” he said. “They are drugs that can make you sleep if you give them in high doses in the ER, but they’re not designed for that at all, and they’re much riskier than drugs for sleeping.”

Montreal police (SPVM) acknowledge there has been a significant increase in fatal and non-fatal opioid overdoses since the start of the COVID-19 pandemic.

In addition, the quality of drugs has declined.

“Some dealers cut their merchandise further with various products, including fentanyl in the case of heroin,” said the force.

STRONGER THAN MORPHINE

Isotonitazene was first synthesized in the mid-1950s in an attempt to develop safer opioid analgesics with levels higher than morphine.

It has since emerged on the illicit drug market in North America and Europe, according to the United Nations Office on Drugs and Crime.

It was first identified in Europe in April 2019.

One year later, the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) started receiving reports specifying isotonitazene in seized drug samples and toxicology cases across the European Union.

Around the same time, the substance was linked to eight deaths in the United States.

More locally, traces of the drug have been found in the autopsies of 14 people since August 2020, according to the Montreal Public Health Department (DRSP).

In fact, the department issued an overdose alert in November 2020 about the circulation of tablets that look like oxycodone but actually contain isotonitazene.

The drug can appear in numerous forms, including tablets and powder, and carries a high risk of overdose.

“Use of this substance can cause respiratory distress up to and including respiratory arrest and even death,” the DRSP stresses.

Naloxone can be used to reverse the effects of isotonitazene, but given its potency, more than one dose may be needed to save a person’s life.

Vadeboncoeur argues anything bought on the street is dangerous and could potentially kill.

“There can be stuff out there that can take your life,” he stresses.

Isotonitazene identified in Toronto’s unregulated drug supply

April 22, 2021 Download PDF Share

What is the purpose of this alert?

For the first time, Toronto’s drug checking service has identified isotonitazene in Toronto’s unregulated drug supply. Isotonitazene has now presented in 2 expected fentanyl samples, alongside fentanyl, heroin, and the benzodiazepine-related drug, etizolam. The presence of isotonitazene was not expected by those who submitted these samples to be checked.

These samples were collected in Toronto’s west end and downtown core. One of these samples was known to be associated with an overdose.

What is isotonitazene?

Isotonitazene is an opioid that was synthesized in the 1950s to relieve pain. While isotonitazene was never clinically approved for market, it has, in recent years, presented in the unregulated drug supply. Isotonitazene is believed to be highly potent: some studies conducted on animals suggest isotonitazene could be 5 times stronger than fentanyl. Isotonitazene is sometimes known as “iso.”

What are the potential effects of using isotonitazene?

Isotonitazene produces effects similar to other opioids like morphine and fentanyl, including euphoria, relaxation, sedation, slowing of heart rate and breathing. However, because of its strength, the chance of overdose from using isotonitazene is increased, and greater than normal doses of naloxone may be required to arouse individuals experiencing an overdose.

When isotonitazene is used in combination with other opioids or other central nervous system or respiratory depressants, like benzodiazepine-related drugs, the risk of dangerous suppression of vitals is increased (e.g., slowing down of breathing, blood pressure, heart rate). This is noteworthy since over 60% of opioid samples checked by Toronto’s drug checking service have contained more than 1 type of opioid or an opioid and a benzodiazepine-related drug.

Use of isotonitazene may result in death. The European Monitoring Centre for Drug and Drug Addiction recently reported the presence of isotonitazene in 23 deaths across Canada, the United States, Germany, and the United Kingdom.

Advice to reduce potential harms:

1. Carry and be trained to use naloxone. Naloxone, also known by the brand name Narcan, is a drug that can temporarily reverse an opioid overdose. Naloxone can be picked up for free from your local harm reduction agency or pharmacy and free training is available online. Consider carrying multiple doses of naloxone.
2. Get your drugs checked before using. In Toronto, drug checking services are offered at Moss Park Consumption and Treatment Service, Parkdale Queen West Community Health Centre (Queen West and Parkdale sites), South Riverdale Community Health Centre, and The Works at Toronto Public Health. You can also check your drugs after you have used them by submitting paraphernalia, like a cooker or a filter.
3. Use at a supervised consumption site. Here is a list of sites that offer supervised consumption in Toronto and an interactive map of sites that offer supervised consumption across Canada.
4. Use with someone else and take turns spotting for each other. A buddy system is safer than using alone. Stay 6 feet from your buddy if you are not from the same household to avoid passing COVID-19.
5. If you must use alone, let someone know before you use. Call someone you know and have them stay on the phone with you while you use. Tell them your address and keep your door unlocked. If you are in Ontario, you could call the Overdose Prevention Line at 1-888-853-8542. The National Overdose Response Service is available to anyone in Canada and can be reached at 1-888-688-NORS (6677). BeSafe is an app that can be downloaded on your phone and provides another way to let someone know before you use.
6. Do a small test dose first.
7. Call 911 in an overdose situation. The Good Samaritan Drug Overdose Act provides legal protection from drug-related charges for carrying drugs for personal use and other simple possession offences.
8. If your drugs did not contain what you were expecting, consider talking to the person you got your drugs from, or get your drugs from another source if possible.