Description

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Etomethazene (5-methyldesnitroetonitazene, 5-methyl etodesnitazene, Eto) is a benzimidazole derivative with opioid effects which has been sold as a designer drug over the internet since 2022, first being definitively identified in Sweden in January 2023.^[1]^[2] It is an analogue of etonitazene where the nitro (NO₂) group has been replaced by a methyl (CH₃) group. While formal studies into its pharmacology have yet to be carried out, it showed far less potency than etonitazene itself. Etomethazene has an analgesic potency around 20 times that of morphine with a relatively short duration of about 120 min. Buy Etomethazene powder Cas 95293-25-7

Description

Etomethazene(5-methyldesnitroetonitazene) is an opioid analgesic, a derivative of benzimidazole, a recreational research substance with high opioid activity, approximately 120-140 times stronger than morphine. This substance has become known since 2022 as a recreational drug sold online. Buy Etomethazene powder Cas 95293-25-7

Chemistry

Etomethazene is a derivative of benzimidazole, an analogue of etonitazene and has a related chemical structure, where the NO2 nitro group is replaced by methyl CH3.

Pharmacology, Pharmacodynamic

Studies of this substance in mice have shown that it is an active agonist of the µ-opioid recetors and acts as a strong analgesic, causing sedative, hypnotic effects, causing the characteristic opioid ephoria.

Side effects

With improper use, high dosage, as well as use with other drugs, side effects such as respiratory depression, dizziness, nausea, itching and constipation, physical and psychological addiction are possible.

Medical applications

Etomethazene is a designer research drug and has never been used for medical purposes.

Dosage

The exact dosage is not known, due to the lack of proper medical research. It has been established that Etomethazene is a potent analgesic with high opioid activity, therefore it is necessary to be extremely careful with dosages.

Legal status

United States: an analogue of etonitazene.

Technical Information:

Product Name Etomethazene

Synonyms 5-methyl Etodesnitazene

IUPAC Name 2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-5-methyl-1H-benzimidazole-1-ethanamine

2-[2-[(4-ethoxyphenyl)methyl]-5-methylbenzimidazol-1-yl]-N,N-diethylethanamine

CAS Number

Molecular Formula C₂₃H₃₁N₃O

Formula Weight 365.5 g/mol

InChi Code InChI=1S/C23H31N3O/c1-5-25(6-2)14-15-26-22-13-8-18(4)16-21(22)24-23(26)17-19-9-11-20(12-10-19)27-7-3/h8-13,16H,5-7,14-15,17H2,1-4H3/h5-10,14-15,22H,4,11-13H2,1-3H3

InChi Key ZARKNPABJGEAOQ-UHFFFAOYSA-N

SMILES CCN(CC)CCN1C2=C(C=C(C=C2)C)N=C1CC3=CC=C(C=C3)OCC

Solubility

DMF: 12 mg/mL

DMSO: 10 mg/mL

Ethanol: Slightly soluble

PBS (pH 7.2): 5 mg/mL

Formulation A solid

Purity ≥98%

not for human use

Disclaimer of liability

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Etomethazene is intended only as a substance for scientific and research purposes in special laboratory conditions in compliance with all standards and safety measures.

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Etomethazene (5-methyl Etodesnitazene, IUPAC: 2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-5-methyl-1H-benzimidazole-1-ethanamine) is an opioid analgesic, benzimidazole class, structurally similar to etonitazene, but without alkyl groups listed in R3 and R4, etomethazene has a methyl group on R4.
This opioid has high opioid potency about 2 times higher than etonitazene and 120 times stronger than morphine.
Its dosage is 0.3-0.5 mg minimum, 1 mg medium, and 1.5 mg high, and these conclusions were made after testing and research in rodents. This drug may cause opioid dependence, and also to this drug develops a rapid tolerance and requires an increase in dosage. High dosages may cause side effects such as vomiting and respiratory depression.
This drug is relatively new and classified as a dosage formulation; its pharmacological and toxicological properties are not fully understood and it is intended for research and testing in specially equipped laboratories.

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Product information

IUPAC 2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-5-methyl-1H-benzimidazole-1-ethanamine

Synonyms Etomethazene, 5-methyl Etodesnitazene

Formal Name 2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-5-methyl-1H-benzimidazole-1-ethanamine

CAS

Formula C₂₃H₃₁N₃O • C₆H₈O₇

Molecular Weight 557.6

Purity 98.0 % min.

Formulations A solid

Appearance A solid

Solubility

DMF: 12 mg/mL
DMSO: 10 mg/mL
Ethanol: Slightly soluble
PBS (pH 7.2): 5 mg/mL

Shipping & Storage Information

Storage -20°C

Shipping Wet ice in continental US; vary elsewhere

Stability ≥ 2 years

Etonitat and its related opioid agonist benzimidazole were discovered in the late 1950s by a team of Swiss researchers working at the pharmaceutical company CIBA (now Novartis). One of the first compounds studied by the Swiss team was 1-(beta-diethylaminoethyl) -2-benzyl benzimidazole, which was found to have 10% of morphine’s analgesic activity in rodent bioassometry. This finding encouraged the team to begin a comprehensive systematic study of 2-benzyl benzimidazole and to establish the structural-activity relationship for this new family of painkillers. Two general synthesis methods were developed to prepare these compounds. The first method involves the condensation of o-phenylenediamine with phenylacetonitrile to form 2-benzylbenzimidazole. The benzimidazole is then alkylated with the desired 1-chloro-2-dialkyl aminoethane to form the final product. This particular method is most useful for preparing benzimidazole without substituents on the benzene ring The most general synthesis [4] developed by the Swiss team first involves the alkylation of 2, 4-dinitrochlorobenzene with 1-amino-2-diethylaminoethane to form N-(β-diethylaminoethyl)-2, 4-dinitroaniline [aka: N’- (2, 4-dinitrophenyl) -n, n-diethyl-ethane-1, 2-diamine]. The 2-nitro substituents on 2, 4-dinitroaniline compounds are then selectively reduced to corresponding primary amines by using ammonium sulfide as reducing agent. Ammonium sulfide can form hydrogen sulfide gas in situ by adding a concentrated ammonium hydroxide solution and saturating it with the solution. An intermediate formed by the selective reduction of 2-nitro-substituent 2-(β-diethylaminoethyl aminoethyl) -5-nitroaniline, which then reacts with the iminoethyl ether hydrochloride of 4-ethoxy phenylacetonitrile (aka: p-ethoxy benzyl cyanide). Iminoether, 2-(4-ethoxy phenyl) -acetyliminoate ethyl ester hydrochloride, is prepared as a gas by dissolving 4-substituted benzyl cyanide in a mixture of anhydrous ethanol and chloroform, and then saturating the solution with anhydrous hydrogen chloride. The reaction between 2-(beta-dialkyl aminoalkyl amine) -5-nitroaniline and the hydrochloride of iminoethyl ether results in the formation of etonitrazine. The procedure is particularly suitable for the preparation of 4-, 5-, 6- and 7-nitrobenzimidazole. The selection of altered substituted iminoethers of phenylacetic acid can provide compounds with multiple substituents at the benzene 2-site Many analogues are known, the only other notable compound derived from the original study in the 1950s is clonitacetone, which is much weaker than etonissini (about 3 times morphine). More recently, since around the end of 2018, a number of designer analogues have started to appear on the illegal market around the world, with the most prominent compounds being metronidazole, Buy Etomethazene powder Cas 95293-25-7, Buy Etomethazene powder Cas 95293-25-7, Buy Etomethazene powder Cas 95293-25-7, Buy Etomethazene powder Cas 95293-25-7, Buy Etomethazene powder Cas 95293-25-7, Buy Etomethazene powder Cas 95293-25-7, Buy Etomethazene powder Cas 95293-25-7, Buy Etomethazene powder Cas 95293-25-7, Buy Etomethazene powder Cas 95293-25-7, Buy Etomethazene powder Cas 95293-25-7

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selling Etomethazene powder Cas 95293-25-7

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