Description
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Buy N-Desethyl Etonitazene online. N-Desethylisotonitazene (norisotonitazene) is a benzimidazole opioid with potent analgesic effects which has been sold as a designer drug. It was first identified in 2023 as an active metabolite of the closely related compound isotonitazene, and was found to have similar potency. It is one of the strongest benzimidazole opioids discovered, with an analgesic strength 20 times stronger than fentanyl.
Starting in 2023, it has become an increasingly widespread drug of abuse in its own right, linked to numerous overdose cases, and may be considered an analog of the schedule 1 drug metonitazene. In October 2023, the DEA published an intent to temporarily schedule etonitazepipne and N-desethylisotonitazene. As of April 2024, it is not yet controlled in the United States
Technical Information
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Formal Name
2-[(4-ethoxyphenyl)methyl]-N-ethyl-5-nitro-1H-benzimidazole-1-ethanamine
CAS Number 2732926-26-8
Molecular Formula C20H24N4O3
Formula Weight 368.4
Purity ≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/ml
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 10 mg/ml
λmax
241 nm
SMILES
CCNCCN1C2=CC=C([N+]([O-])=O)C=C2N=C1CC3=CC=C(OCC)C=C3
InChi Code
InChI=1S/C20H24N4O3/c1-3-21-11-12-23-19-10-7-16(24(25)26)14-18(19)22-20(23)13-15-5-8-17(9-6-15)27-4-2/h5-10,14,21H,3-4,11-13H2,1-2H3
InChi Key
RESPFUMJVJRUMB-UHFFFAOYSA-N
Shipping & Storage Information
Storage -20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
N-desethyl etonitazene and protonitazepyne: “New” nitazene opioids circulating in Toronto’s unregulated opioid supply
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For the first time, Toronto’s Drug Checking Service has identified N-desethyl etonitazene and protonitazepyne in Toronto’s unregulated opioid supply.
N-desethyl etonitazene and protonitazepyne are high-potency synthetic nitazene opioids. N-desethyl etonitazene is considered to be up to 10 times stronger than fentanyl. Protonitazepyne, also known as N-pyrrolidino protonitazene, is considered to be more than 20 times stronger than fentanyl.
N-desethyl etonitazene was first identified by our analysis site member at the Centre for Addiction and Mental Health (Clinical Laboratory and Diagnostic Services) on February 23, 2024. The sample was collected in Toronto’s west end by our collection site member at the Queen West Site of Parkdale Queen West Community Health Centre. The sample was a yellow/beige powder that was expected to be (i.e., got or bought as) fentanyl. The sample did not contain fentanyl – it instead contained N-desethyl etonitazene and caffeine. Toronto’s Drug Checking Service does not currently quantify N-desethyl etonitazene and therefore cannot speak to how much of it was present in the sample. The sample was not reported as being associated with an overdose or other unpleasant or abnormal effects.
Protonitazepyne was first identified by our analysis site member at the Centre for Addiction and Mental Health (Clinical Laboratory and Diagnostic Services) on March 6, 2024, and again the following day on March 7. The samples were collected in Toronto’s west end by our collection site member at the Parkdale Site of Parkdale Queen West Community Health Centre. The samples were blue powders that were expected to be oxycodone (OxyContin). The samples did not contain oxycodone – they instead contained protonitazepyne and etonitazepyne (also known as N-pyrrolidino etonitazene and considered to be more than 20 times stronger than fentanyl). Toronto’s Drug Checking Service does not currently quantify protonitazepyne or etonitazepyne and therefore cannot speak to how much of them were present in the samples. The samples were not reported as being associated with an overdose or other unpleasant or abnormal effects.
What are nitazene opioids?
Nitazene opioids were synthesized in the 1950s to relieve pain but were never clinically approved for market. Most nitazene opioids are considered to be stronger than fentanyl – and therefore classified as “high-potency opioids” by Toronto’s Drug Checking Service. Around 2019, nitazene opioids began presenting in the unregulated drug supply in Europe, the United States, and then Canada. In Canada, nitazene opioids have been especially prevalent in the eastern provinces – primarily Ontario and Quebec.
Toronto’s Drug Checking Service first identified a nitazene opioid in Toronto’s unregulated fentanyl supply in February 2021. Between February 12, 2021, and March 8, 2024, Toronto’s Drug Checking Service:
- Has identified 10 different nitazene opioids in samples checked, including 4′-hydroxynitazene, 5-aminoisotonitazene, etodesnitazene, etonitazene, etonitazepyne, isotonitazene/protonitazene, metonitazene, N-desethyl etonitazene, N-desethyl isotonitazene, and protonitazepyne. You can learn more about these drugs, including their suspected strength as compared to fentanyl in our Drug Dictionary.
- Has reported nitazene opioids 555 times in 474 samples. The vast majority of these samples were expected to be fentanyl (418 of 474).
- Has observed significant variation in the number of expected fentanyl samples that contain nitazene opioids. Between January 1 and March 8, 2024, nitazene opioids were found in 3% of the expected fentanyl samples checked, as compared to 22% between January and March 2022.
- Has found nitazene opioids in 25 other expected opioid samples, including those expected to be oxycodone (OxyContin) (9 of 474), Percocet (5 of 474), hydromorphone (Dilaudid) (4 of 474), heroin (3 of 474), and hydrocodone (2 of 474). Two samples containing nitazene opioids were expected to be a nitazene opioid.
- Has not confirmed nitazene opioid contamination in samples that were expected to be other drug types, such as stimulants, psychedelics, dissociatives, or depressants.
What are the potential effects of using N-desethyl etonitazene and protonitazepyne?
- Since N-desethyl etonitazene and protonitazepyne are so strong, the risk of overdose in increased and greater than normal doses of naloxone may be required to rouse individuals experiencing an overdose.
- The risk of overdose may be further increased for people who use oxycodone (OxyContin), Percocet, hydromorphone (Dilaudid), or hydrocodone, as compared to people who use fentanyl, because their opioid tolerance may be lower.
- In expected fentanyl samples, high-potency opioids are often found in combination, likely increasing the strength of the opioids being used and, therefore, increasing the risk of overdose. For example, between January 1 and March 8, 2024, 42% of the expected fentanyl samples checked by Toronto’s Drug Checking Service contained more than one high-potency opioid.
- In expected fentanyl samples, high-potency opioids are often found in combination with other central nervous system and/or respiratory depressants, such as benzodiazepine-related drugs and veterinary tranquilizers. For example, between January 1 and March 8, 2024, 58% of the expected fentanyl samples checked by Toronto’s Drug Checking Service contained at least one benzodiazepine-related drug and/or veterinary tranquilizer. Using high-potency opioids in combination other central nervous system and/or respiratory depressants increases the risk of dangerous suppression of vitals (e.g., slowing down of breathing, blood pressure, heart rate).
Advice to reduce potential harms associated with using N-desethyl etonitazene and protonitazepyne:
- Carry and be trained to use naloxone. N-desethyl etonitazene and protonitazepyne are opioids, meaning naloxone should reverse their effects in an overdose situation. However, since N-desethyl etonitazene and protonitazepyne are so strong, greater than normal doses of naloxone may be required to rouse individuals experiencing an overdose. Oxygen is often also provided in community health settings as a comprehensive overdose response, specifically when benzodiazepine-related drugs and/or veterinary tranquilizers are present, and overdoses are therefore only partially reversed with naloxone.
- Get your drugs checked, ideally before using, and providing services are available to you.
- Use at a supervised consumption site or overdose prevention site – or with someone else and take turns spotting each other.
- If you must use alone, let someone know before you use.
- Do a small test dose first.
- If your drugs did not contain what you were expecting, consider talking to the person you got your drugs from, or get your drugs from another source if possible.
View more general harm reduction tips and help on our website.
Which drug checking technologies can identify N-desethyl etonitazene and protonitazepyne at this time?
- Our analysis site member at the Centre for Addiction and Mental Health (Clinical Laboratory and Diagnostic Services) has identified N-desethyl etonitazene and protonitazepyne using liquid chromatography-Orbitrap high resolution mass spectrometry (LC-HR-MS).
- Our analysis site member at St. Michael’s Hospital (Department of Laboratory Medicine) has identified N-desethyl etonitazene and protonitazepyne using gas chromatography-mass spectrometry (GC-MS).
- Health Canada’s Drug Analysis Service (DAS) has identified protonitazepyne using GC-MS, nuclear magnetic resonance spectroscopy (NMR), and gas chromatography-infrared spectroscopy (GC-IR) in samples submitted by Canadian law enforcement agencies and public health partners. They have not yet identified N-desethyl etonitazene.
- N-desethyl etonitazene and protonitazepyne are not currently included in the library for the paper spray-mass spectrometer (PS-MS) used by the University of Victoria’s Substance project, however, they are in the process of updating their library.
- Some Fourier transform infrared spectrometer (FTIR) libraries, such as Kykeon Analytics’, include protonitazepyne. However, it is likely that protonitazepyne would account for less than 5% of the sample, meaning it would fall below the FTIR’s limit of detection and therefore be missed by instrument. To minimize this limitation, FTIR is often coupled with test strips, which are more likely to identify substances in trace amounts. Based on publicly available information, it is unlikely nitazene test strips can identify N-desethyl etonitazene and protonitazepyne.
- It is unlikely that emerging onsite drug checking technologies can identify N-desethyl etonitazene and protonitazepyne at this time as their libraries are being developed and their limits of detection are being determined.
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Schedules of Controlled Substances: Temporary Placement of N-Desethyl Isotonitazene and N-Piperidinyl Etonitazene in Schedule I
Etonitazene
Etonitazene or etodesnitazene (2-{2-[(4-ethoxyphenyl)methyl]− 5-nitro-1H-benzimidazol-1-yl}-N,N-diethylethan-1-amine) was the first compound from the nitazene group encountered on the illicit drug market. In MOR activation assays monitoring either β-arrestin2 or mini-Gi recruitment etonitazene was 22-times (β-arrestin2) and 20-times (mini-Gi) more potent than fentanyl [60].
The presence of etonitazene in a form of a “brownish looking powder” was reported in Italy in the late 1960 s, in Germany in 1987, in Russia in 1998, and in the US in 2003. Etonitazene was not only a potent but also a highly selective MOR ligand (reviewed in [8]). N– and O-deethylation were identified as the predominant metabolism routes of etonitazene, resulting in O-deethylated etazene, N-deethylated etazene and N,O-dideethylated etazene. Less abundant hydroxylated products of the listed above deethylated metabolites were also found
N-desethyl Etonitazene is an opioid analgesic, a derivative of benzimidazole, an active metabolite of atrazine and has a similar molecular structure and has a high opioid activity. This drug atktivno affects the µ-opioid receptors, providing a strong analgesic effect, hypnotic effect. N-desethyl Etonitazene has a potency 60 times or more stronger than morphine. Regular use of N-desethyl Etonitazene can cause opioid addiction, tolerance to the drug develops, with high dosages, side effects such as vomiting, confusion of consciousness, respiratory depression are possible.
This drug is prohibited for import and sale in the United States and some other countries.
This drug is a designer and there is no exact data on its dosages and side effects.
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Description:
| Synonyms |
|
| IUPAC | 2-[(4-ethoxy |
| Formula | C20H24N4O3 |
| Molecular weight | 368.4 |
| CAS | 2732926-26-8 |
| Appearance | A crystalline solid, Powder |
| Purity | ≥ 98 % |
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Isotonitazene — commonly referred to as “iso ,nitazene , n-desethyl isotonitazene “, like etonitazene, is a benzimidazole-derived opioid analgesic medication that has been sold as a designer drug. In animal studies, it has about half the potency of etonitazene, but it is likely to be less potent in humans, as was the case with etonitazene (1000 times as potent as morphine in animal models yet only 60 times as potent in humans). Buy Isotonitazene online from Rcchemsupply.net
Fentanyl Powder is 100 times more powerful than morphine in humans. As a result, it can’t be twice as strong as etonitazene while also being 60 times as potent as morphine.
We are not responsible for the manner or purpose of the use of these chemicals. We do not have or are in any way responsible for the use of any chemical.
What is Isotonitazene ?
Isotonitazene is a benzimidazole-derived opioid analgesic drug that is connected with etonitazene and has been sold as an originator drug. It is an intense manufactured narcotic that has arisen on the unlawful medication market, with compound and pharmacological qualities like other mu-narcotic receptor agonists like fentanyl.
Chemistry of Isotonitazene
The proper name of the medication is Isotonitazene and the atomic equation is C23H30N4O3. It has its drug use and is likewise a compelling substance for lab tests. Many individuals who are utilizing isotonitazene are doing so unconsciously. This fashioner drug has been viewed as squeezed into tablets that look like other less powerful narcotics and is additionally being added to cocaine and heroin supplies.
| Property | Value |
|---|---|
| Common Name | Isotonitazene, iso ,nitazene |
| IUPAC name | N,N-diethyl-2-[2-[(4-isopropoxyphenyl)methyl]-5-nitro-benzimidazol-1-yl]ethanamine |
| CAS Number | 14188-81-9 |
| PubChem CID | 145721979 |
| Chemical formula | C23H30N4O3 |
| Molar mass | 410.518 g·mol−1 |
| Purity | ≥98% |
| SMILES | CCN(CCn1c(Cc2ccc(cc2)OC(C)C)nc2c1ccc(c2)N(=O)=O)CC |
| InChI | InChI=1S/C23H30N4O3/c1-5-25(6-2)13-14-26-22-12-9-19(27(28)29)16-21(22)24-23(26)15-18-7-10-20(11-8-18)30-17(3)4/h7-12,16-17H,5-6,13-15H2,1-4H3 |
| Routes of administration | By mouth, nasal spray, e-vape |
N,N-diethyl-2-(2-(4-isopropoxybenzyl)-5-nitro-1H-benzimidazol-1-yl)ethan-1-amine is the chemical name for isotonitazene.
chemical synthesis of schedule I drugs like isotonitazene
Etonitazene and clonitazene are two examples of synthetic opioids with a benzimidazole core that were initially discovered in the late 1950s.
If you’re looking for a medication that can help to improve your heart health, Isotonitazene may be a good option for you. This medication can help improve the function of your heart, and it can also help reduce the risk of heart attack or stroke.
Why Isotonitazene could be stronger than etonitazene
Many of the components in each drug are the same. While etonitazene is made from a benzimidazole precursor (phenanthrenes and benzofuran) that also makeup phenacetin, n-desethyl isotonitazene is synthesized from benzyl phenyl using a 1,4-pentylenetetrazole decarboxylation step. So Isotonitazene or Protonitazene might be potent enough to get around the synthetic compound. Deoxymethoxetamine (DMXE)
The basis of opiate action is its chemical structure. It’s made up of a benzimidazole ring with the N-methyl attached. The N-methyl is a functional group, and although it’s one that’s been known for centuries to cause pain, it’s not all that well known. Because the ring that’s part of etonitazene is much larger, more commonly known as the anode, that part is known to be the point of greatest activation of pain receptors. buy etizolam powder USA
Isotonizene in comparison to other opioids
As with other benzimidazoles, Isotonitazene is a full agonist at both μ-opioid receptors, which leads to an analgesic effect. It is about 10-15 times more potent than morphine (in animal models) and about the same as codeine (human); similar to other benzimidazoles, it produces a lowered respiratory rate (relief of breathlessness) in animal studies, but not in human studies (data not available). Buy Isotonitazene online
The full agonistic potency of Isotonitazene is responsible for the analgesic effects, which are more focused than other opioids, and its relatively high binding affinity at μ-opioid receptors is a positive indication of a favorable tolerability profile in the use of this opioid in humans. MXiPr
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Isotonitazene is not chemically interchangeable with fentanyl, which does not have a strong affinity for mu-opioid receptors, nor with etonitazene, which does. To date, the most common use of Isotonitazene is as a new synthetic form of fentanyl, marketed as a legal high, in a variety of flavors. Dissociatives For Sale
It is easy to order online from Rcchemsupply.net. Another derivative of fentanyl is naloxone hydrochloride (marketed under the name Narcan), which can be used to treat opioid overdoses. Naloxone hydrochloride is a narcotic antidote with a high risk of dependence and addiction. Buy etonitazene online
Isotonitrile, like Isotonitazene, is a benzimidazole-derived opioid analgesic medication that has been sold as a designer drug. In animal studies, it has about half the potency of etonitazene, but it is likely to be less potent in humans, as was the case with etonitazene (1000 times as potent as morphine in animal models yet only 60 times as potent in humans). Buy Isotonitrile Online from Rcchemsupply.net with bitcoin
How to order Isotonizene online
Another design feature of n-desethyl isotonitazene is that it is only slightly lipophilic, which means that it is only slightly soluble in water. This makes it harder to make with clandestine laboratories. Due to this, it has a longer duration than etonitazene, which does not. In other words, you can go to sleep and wake up without being dopey for the following day. Buy Isotonizene Online from Rcchemsupply.net | Isotonizene
How do I use Isotonitazene?
Isotonitazene can be administered in the following ways: Intravenously Subcutaneously Oral Can I take more than one dose of Isotonitazene? Yes. When taking more than one dose, a series of partial dose regimens is often recommended to prevent undesirable side effects such as drowsiness. Can I take Isotonitazene with Benzo Percocet? Not with Benzo Percocet. Can Isotonitazene cause a reaction at my site? In general, short-term or minor pain is not a common side effect of Isotonitazene, but it may occur.
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Online pharmacies like Rcchemsupply.net, stock medical-grade Isotonitazene for use in research labs. Medical-grade Isotonitazene usually is available by prescription only in Europe and the United States. . Buy Etonitazene powder
Comparing Isotonitazene to Other Opioids
Understanding how isotonitazene compares to other opioids is essential for researchers and individuals considering its use.
Isotonitazene vs. Morphine
Isotonitazene exhibits much higher potency than morphine, making it an attractive option for researchers studying pain management.
Isotonitazene vs. Fentanyl
Fentanyl is another potent opioid, and isotonitazene’s effects are comparable in strength. Researchers may find interest in studying the differences and similarities between these compounds.
Abuse and Its Effects
Isotonitazene is a benzimidazole inferred narcotic pain relieving drug-connected with etonitazene, which has been sold as a fashioner drug. It has just around a portion of the power of etonitazene in creature studies, however this actually makes it a comparable solidarity to fentanyl and its analogs, and subsequently, isotonitazene can be anticipated to represent a huge danger of delivering hazardous respiratory melancholy, as well as other normal narcotic secondary effects like sedation, tingling, sickness, and retching. We are the online Isotonitazene powder provider with the best lawful substance supply.
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4-Methoxy-N-ethyl-N-ethyl-piperidinone (XPS), heroin, morphine, dextromoramide, and Isotonitazene are three of the most common compounds that can be found illegally in the United States. Isotonitazene is the most potent opioid analgesic that can be manufactured. Not only that, but it is also less addictive than common, commonly available opioids. It’s also available in the UK. The user may be oblivious to any potential dangers of purchasing synthetic opioids such as iIsotonitazenefrom online sites.
N-desethyl Etonitazene (Des-Eto) is an opioid analgesic, a benzimidazole derivative, a metabolite of ethonitazene, has a similar structure and properties.
It has excellent analgesic, hypnotic properties, can cause euphoria, soothes. This substance has a high opioid activity equal to etonitazene, which can only be compared with strong opioid drugs. High dosages of the drug can cause side effects, such as respiratory depression up to death.
N-desethyl Etonitazene is not prohibited for scientific and research purposes in many countries of the world, including EU countries, but this drug may be subject to the law on analogues of etonitazene, as, for example, in the United States.
N-desethyl Etonitazene is a designer opioid drug and its toxicological and pharmacological properties are under investigation and not fully understood. This chemical is intended for research and identification of properties, in special rooms, on special laboratory equipment, in compliance with all safety measures.
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| CAS | 2732926-26-8 |
| Product Name | N-desethyl Etonitazene, Des-Eto, Desethyl Etonitazene |
| Molecular Formula | C20H24N4O3 |
| Molecular Weight | 368.4 |
| IUPAC Name | 2-[(4-ethoxy |
| InChI |
InChI=1S/C20H24N4O3/c1-3-21-11-12-23-19-10-7-16(24(25)26)14-18(19)22-20(23)13-15-5-8-17(9-6-15)27-4-2/h5-10,14,21H,3-4,11-13H2,1-2H3
Key: RESPFUMJVJRUMB-UHFFFAOYSA-N
|
| Solubility |
|
| Synonyms | N-desethyl Etonitazene, Des-Eto, Desethyl Etonitazene |
| Purity | ≥98% |
| Formulation | A crystalline solid, Powder |
| Storage | -20°C |
| Stability | ≥ 2 years |
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